Remote tribe in Bolivia confounds health vertities

Remote tribe in Bolivia
confounds health vertities


By the University of Southern California news service


Heart attacks and strokes — the leading causes of death in the United States and other developed countries — may have been rare for the vast majority of human history, suggests a study published this week in the scientific journal PLoS ONE.

“Understanding how physiological systems respond in populations helps us better understand conditions in countries like the United States at the beginning of the 20th century,” said senior author Eileen Crimmins of the University of Southern California Davis School of Gerontology. “This also offers some insight into the worlds we evolved in.”
Professor Crimmins, lead author Michael Gurven of the University of California, Santa Barbara, and an international team of scientists looked at a remote Amazonian tribe in Bolivia known as the Tsimane. They measured various predictors of heart disease such as hypertension, obesity, diet and smoking habits. The Tsimane grow and harvest their own tobacco.

“The Tsimane were chosen because they still live a relatively traditional lifestyle: fishing, hunting, engaged in horticulture, gathering, living in extended family clusters and without much access to modern amenities,” Gurven explained. “There are other groups with similar lifestyles, but often those groups have very small population numbers. The Tsimane population is large enough — about 9,000 — that we can study almost all of the adults over age 40.”

With only limited access to medical services, half of the documented deaths among the Tsimane are due to infectious or parasitic disease. About two-thirds of the population has intestinal worms, the researchers found.

“We looked at a lot of populations in both developed and developing countries, in urban and rural settings, but none live in the relatively isolated and infected conditions of the Tsimane,” the researchers wrote.

Chronic inflammation, which may lead to damage of the arteries, is prevalent among the Tsimane. According to the study, the Tsimane also have unusually high levels of C-reactive protein, increasingly used in clinical settings to evaluate risk for cardiovascular disease.

Yet, despite these risk factors for heart attacks, the researchers found that the high levels of C-reactive protein were unrelated to risk of peripheral arterial disease, the hardening of plaque in the arteries.

In fact, peripheral arterial disease “increases with age in every investigated population except the Tsimane,” according to the study. Among the Tsimane, not a single adult showed evidence for peripheral arterial disease when measured using the ankle-brachial blood pressure index.

“Neither demographic interviews nor the past seven years of working with the Tsimane has turned up many overt cases of people dying from heart attacks,” Gurven said. “The Tsimane data tell us that inflammation alone may not be destructive in terms of its effects on long-term health. However, that might only be true in the context of an active lifestyle, lean diet and possibly with a history of parasitism.”

The researchers noted that the Tsimane may have a distinct genetic expression compared to people in developed countries. Specifically, there is overexpression of the human leukocyte antigen, which has been linked in cell studies to plaque erosion.

“We observed low levels of atherosclerosis and associated cardiovascular disease among Tsimane, suggesting that these conditions may have been rare throughout pre-industrial human history,” Crimmins said. “We may not be built for the world we live in. The Tsimane are perhaps a better model for the world we are built for.”

Researchers don’t know for sure that as younger people today get older that arterial disease won’t increase, Gurven said. “More heart disease may be on the horizon if lifestyles change rapidly.”

La Fortuna area finds
pr bonanza in TV's 'Lost'


By the A.M. Costa Rica staff


Five persons, four Colombians and a Brazilian, are in Costa Rica as winners of a contest sponsored in part by the Instituto Costarricence de Turismo. The contest revolves around the television series "Lost," and one of their hosts here is Jorge Garcia, a star of the show. He plays Hugo.

The five participated in a contest run by the network AXN and were awarded with four days and three nights in the La Fortuna area. The contest participants had to submit a video related to the show, and viewers voted.

Tourism officials said they are thrilled that the La Fortuna area and the Arenal volcano will be featured on a television program about the winners.